Kandarin
Kandarin is the most westerly of the human nations, and by far the most complex.The capital, Ardougne, is divided down the middle and large dark walls mark this clearly. This is the result of the former king's decision to split his kingdom between both of his sons. Now, King Lathas rules the prosperous eastern half of the city while King Tyras has largely abandoned his side to lead a crusade through the Underground Pass.
On top of the feuding of the two kings of Kandarin, the lands themselves are oddly perforated with the outposts and settlements of other races. South of Ardougne is the Tree Gnome Village, an odd maze designed to protect the gnomes within from invasion. Still further south, past Yanille, are the ogre city of Gu'Tanoth and the Feldip Hills; ogres have little concept of borders, though, and can be found in their small tribes dotted around the fields near Yanille.
Despite the odd characteristics that seem to govern Kandarin, it is a wealthy nation and easily as powerful as Misthalin. Ardougne's wealth is supported by the various industries of Yanille, Seers' Village and Catherby, as well as by trading with the other nations around and within Kandarin's borders. There are even rumours that Kandarin has connections with the mysterious lands west of the mountains, where no human has set foot since the God Wars.
The Kharidian Desert
The Kharidian Desert is the most inhospitable of all the lands of RuneScape. Even the mightiest warriors, mages and rangers take care to go into the desert with proper preparations. Somehow, against all that the desert may summon up against them, humans thrive even here. Many thousands of years ago, even before the God Wars, these lands were ruled by the ancient Menaphite deities, but now there is little trace of them save for the few pyramids and other monuments erected either by them or by their followers in later years.
The Kharidian Desert is actually composed of two nations, which is apt as the lands north of the Shantay Pass are both more civilised and more agreeable to unprepared travellers. The city of Al Kharid is ruled by the Emir, though no one has seen him in public since his only son, Prince Ali, was kidnapped. Now he leaves much of the duty of running his small nation to Chancellor Hassan.
The lands south of the Shantay Pass are a constantly shifting and changing morass of sand that bears more in common with the tides of the sea than with any land. Thousands have lost their way (and, hence, their lives) within this place, but the sands shift again and their bones are buried for centuries, only to be unearthed, polished and gleaming, for the jackals to gnaw upon.
There is civilisation here, though, and an ancient one it is. The twin cities of Menaphos and Sophanem rule their lands with the priesthood, worshipping the same deities they have for as long as they have been there. In the western desert is a collection of less orderly places. The Bedabin nomads obey no rule except their own, as do the bandits; the Bedabin, though, are friendly and hospitable people, while the bandits spend much of their lives practicing how to slit throats.
The Fremennik Province
In the far northwest of RuneScape, where the land turns to ice and the stone breathes, the Fremennik make their homes in long timber halls lined with furs. They are a noble people with a definite understanding of their corner of the world. They have adapted to their environment as fully as the people of the Kharidian Desert, and have proven their might at arms in battle against the infamous daggermouths of Waterbirth Island, where the aspiring heroes of the modern age go to meet their deaths in hope of finding glory.
Despite their obvious martial prowess, the Fremennik dislike magic in all its forms, and have a long history of fighting their erstwhile cousins on Lunar Isle.
The Fremennik rule their lands and their waters more completely than any other human nation, for no significant settlement of any other civilised race can be found within their borders.
Miscellania and Etceteria 
Many years ago Fremennik sailors discovered these twin islands, and were astounded by the quality of life that they could foresee there. Since then, the two islands have been built up and populated, and now a complex political situation rules their lives. King Vargas of Miscellania and Queen Sigrid of Etceteria, though both lonely monarchs, have developed a particular enmity, so the two islands are constantly on the brink of open war. It is only the fact that neither island actually has anything approaching a military that has kept them from battle thus far.
Karamja
It is difficult to say that Karamja is a human land, for the jungle fights back at every turn and opportunity. It sends forth legions of hardy, poisonous creatures to slay the humans, and the dense jungle bush wages its own quiet war against the buildings and walls that humans endeavour to build and maintain. Even the native people who live in the village of Tai Bwo Wannai and align their lives with nature as much as possible are forced into fighting this battle. The island, it seems, does not wish to be owned by anyone or anything.
There is evidence of a dark history in Karamja, as the natives know when they speak of the broodoo victims whose death-sleep is as restless as they might expect in Morytania. There are caves and tombs deep in the earth, and mighty beasts that appear once in every few years to terrorise the human population. Karamja may be an island overflowing with untapped wealth, but it is a hard road for anyone who wishes to harness it.
Karamja also plays host to one of the strangest of the races of RuneScape, for beneath the volcano is carved the TzHaar city, where stone and fire find a bizarre life.

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Entrana
Entrana is quite unlike any of the other human lands, it permits no weapons to be brought upon it. Being the home of a devout order of monks, is a fertile and peaceful land that has few fears. The island does not have enough wealth to expect invasion, nor is it aggressive in any way, so it has no foes that do not claim the entirety of humanity as an enemy.